Enzastaurin (LY317615) for cell activation

Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM). Enz suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.

N/A

170364-57-5

515.61

Biochemicals

LY317615, LY-317615, D04014

C₃₂H₂₉N₅O₂

Red-Orange Solid

N/A

No

Yes

≥99% by HPLC

DMSO (5 mg/ml)

-20°C

RT

24months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.