Human CellExp™ BMP-2, Human Recombinant

BMP2 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. BioVision’s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.

N/A

30 to 38 kDa, homodimer, glycosylated.

Human Cellexp Human Recombinant BMP-2

BMP-2, BMP2A

650

BMP2

Human

P12643

Yes

Human 293 cell expressed

≥95%

SDS-PAGE, N/A

< 1.0 EU per 1 μg of protein

N/A

ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).

20 to 100 ng/ml

N/A

N/A

-80°C

gel pack

Lyophilized

Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

N/A

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Recombinants or rec. proteins

recombinants