Human CellExp™ IL-12, Human Recombinant

Catalog number

6467-10

Size

10 µg

Price

344.00 EUR

Supplier

Biovision

Order

Details

Background

IL-12 is a potent regulator of cell mediated immune responses and in induces IFN-Ɣ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN-Ɣ producing Th1 cells.

Concentration

N/A

Molecular weight

57 kDa, heterodimer, glycosylated

Synonym

Human Cellexp Human Recombinant IL-12

Other name

NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-alpha, IL-12.

NCBI gene number

3592

NCBI gene

IL12A

Gene source

Human

NCBI number

P29459

Recombinant

Yes

Source

Human 293 cell expressed

Purification

> 95%

Tested applications

SDS-PAGE, N/A

Level of endotoxin

< 1.0 EU per 1 μg of protein

Tested activity

N/A

Biological activity

ED₅₀ is typically 0.1 to 0.5 ng/mL ng/mL. The specific activity was determined by the dose-dependent release of IFN-gamma from the human NK92 cell line in presence of 20 ng/mL rIL-2.

Reesults

0.1 to 0.5 ng/ml

Binding ability

N/A

Unit

N/A

Storage condition

-80°C

Shipping under

gel pack

Physical appearance

Lyophilized

Physical properties

Lyophilized from a PBS solution.

How to reconstitute

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Aa sequence

N/A

Before use

Centrifuge the vial prior to opening.

Notes

For Research Use Only! Not to be used in humans

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Additional source

Recombinants or rec. proteins

Group

recombinants