NVP-TAE684 for cell activation
Catalog number
1683-5
Name
NVP-TAE684 for cell activation
Size
5 mg
Price
273.00 EUR
Supplier
Details
Description
A potent and selective ALK (anaplastic lymphoma kinase) inhibitor that blocked the growth of ALCL (anaplastic large cell lymphoma)-derived and ALK-dependent cell lines with IC₅₀ = 2-10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK (Nucleophosmin-anaplastic lymphoma kinase) and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.
Peptide sequence
N/A
CAS number
761439-42-3
Molecular weight
614.2
Category
Biochemicals
Other name
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl-N2-(2-methoxy-4-(4-methylpiperazin-1-yl)-piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
Molecular formula
C₃₀H₄₀ClN₇O₃S
Physical appearance
Light yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
