ATM Kinase Inhibitor, KU-55933 for cell activation

A potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively).

N/A

587871-26-9

395.49

Biochemicals

2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933

C₂₁H₁₇NO₃S₂

White solid

N/A

No

Yes

≥97% by HPLC

DMSO (100 mM) and Ethanol (50 mM)

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.