Dorsomorphin for cell activation

Cell-permeable. A potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 µM ATP and no AMP). Does not affect the activity on several structurally related kinases including JAK3, PKA, PKCθ, SYK and ZAPK. Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.

N/A

866405-64-3

399.49

Biochemicals

6-[4-(2-Piperidin-1-yl)-ethoxy)-phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine; Compound C

C₂₄H₂₅N₅O

Light yellow solid

N/A

No

Yes

≥98% by HPLC

DMSO (>5 mg/ml)

+4C

RT

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.