MG-132 for cell activation
Catalog number
1703-5
Name
MG-132 for cell activation
Size
5 mg
Price
164.00 EUR
Supplier
Details
Description
A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC₅₀ = 3 µM). Prevents γ-secretase cleavage.
Peptide sequence
Z-Leu-Leu-Leu-CHO; Z-LLL-CHO
CAS number
133407-82-6
Molecular weight
475.6
Category
Biochemicals
Other name
Z-Leu-Leu-Leu-CHO; Z-LLL-CHO
Molecular formula
C₂₆H₄₁N₃O₅
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (10 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
12 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
