Lactacystin (Synthetic) for cell activation

Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC₅₀ = 10 µM).

N/A

133343-34-7

376.42

Biochemicals

2-(acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid

C₁₅H₂₄N₂O₇S

White solid

N/A

No

Yes

≥95% by HPLC

DMSO (25 mg/ml)

-20°C

gel pack

24 months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.