17-AAG for cell activation
Catalog number
1774-1
Name
17-AAG for cell activation
Size
1 mg
Price
191.00 EUR
Supplier
Details
Description
A semi-synthetic derivative of Geldanamycin (Cat. No. 1564-1,5) that displays greater stability and lower in vivo toxicity compared to Geldanamycin. Binds to Heat shock protein 90 (Hsp90) (EC₅₀ = 7.2 µM) in a manner similar to geldanamycin. Exhibits 100-fold higher affinity for tumor-derived Hsp90 over normal cells. Also inhibits Akt activation and HER2 expression in tumor cells.
Peptide sequence
N/A
CAS number
75747-14-7
Molecular weight
585.69
Category
Biochemicals
Other name
Telatinib; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)geldanamycin; Tanespimycin
Molecular formula
C₃₁H₄₃N₃O₈
Physical appearance
Purple solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (150 mg/ml) or EtOH (5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
