PI3-Kɣ Inhibitor, AS-605240 for cell activation

Cell-permeable. A potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC₅₀ = 8 nM). Displays >33-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.

N/A

648450-29-7

257.27

Biochemicals

5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

C₁₂H₇N₃O₂S

Pink to reddish solid

N/A

No

Yes

≥98% by HPLC

DMSO ( 1 mM)

-20°C

gel pack

48 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.