WP1066 for cell activation

Catalog number
1809-5
Name
WP1066 for cell activation
Size
5 mg
Price
159.00 EUR
Supplier

Details

Description
A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
Peptide sequence
N/A
CAS number
857064-38-1
Molecular weight
356.22
Category
Biochemicals
Other name
(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Molecular formula
C₁₇H₁₄BrN₃O
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97% by HPLC
Reconstitute instructions
DMSO (10 mg/ml) and Ethanol (5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.