WP1066 for cell activation

A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.

N/A

857064-38-1

356.22

Biochemicals

(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide

C₁₇H₁₄BrN₃O

Off-white solid

N/A

No

Yes

≥97% by HPLC

DMSO (10 mg/ml) and Ethanol (5 mg/ml)

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.