Stat3 Activation Inhibitor, SPI for cell activation

Cell-permeable. A potent and selective inhibitor of Stat3 SH2 domain:pTyr interactions; also disrupts the binding of Stat3 to the IL-6R/gp130 peptide, GpYLPQTVNH₂ and induces antitumor effects in vitro.

H-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Thr-Lys-Pro-Pro-Gly-Thr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH

N/A

3225.74. 114.02

Biochemicals

FISKERERAILSTKPPGTFLLRFSESSK

C₁₄₆H₂₃₈N₄₀O₄₂.C₂HF₃O₂

Lyophilized solid

N/A

Yes

Yes

≥95% by HPLC

H₂O

-20°C

gel pack

24 months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.