Leptomycin B for cell activation

A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.

N/A

87081-35-4

540.73

Biochemicals

LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B

C₃₃H₄₈O₆

Liquid

0.2 mg/ml (EtOH)

No

Yes

≥99% by HPLC

N/A

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.