Leptomycin B for cell activation

Catalog number
1814-025
Name
Leptomycin B for cell activation
Size
25 µg
Price
159.00 EUR
Supplier

Details

Description
A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.
Peptide sequence
N/A
CAS number
87081-35-4
Molecular weight
540.73
Category
Biochemicals
Other name
LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B
Molecular formula
C₃₃H₄₈O₆
Physical appearance
Liquid
Supplied with
0.2 mg/ml (EtOH)
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥99% by HPLC
Reconstitute instructions
N/A
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.