CP-31398 Dihydrochloride for cell activation

A styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and promote the activity of wild-type p53 in multiple human cancer cell lines, leading to cell cycle arrest or apoptosis. CP-31398 enhances the protein levels of wild-type p53 by blockade of ubiquitination and degradation of p53 without interrupting the physical association between p53 and MDM2 in vivo.

N/A

1217195-61-3

435.39

Biochemicals

N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride

C₂₂H₂₆N₄O.2HCl

Yellow solid

N/A

No

Yes

≥98% by TLC

H₂O (25 mg/ml) or DMSO (5 mg/ml)

-20°C

gel pack

24 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.