IGF-BP2, human recombinant

Catalog number

7165-50

Size

50 μg

Price

965.00 EUR

Supplier

Biovision

Order

Details

Synonyms

IBP-2

Alternates names

IBP-2

Taglines

Inhibits IGF-II action in human breast and ovarian carcinoma cells

Biomolecule/Target

IGF-BP2

NCBI Gene ID #.

3485

NCBI Gene Symbol

IGFBP2

Gene Source

Human

Accession #

P18065

Recombinant

Yes

Source

(BTI-Tn-5B1-4) Hi-5 Insect cells

Purity

N/A

Endotoxin Level

< 0.1 ng/μg of protein (

Activity (Specifications/test method)

Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Biological activity

Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Results

N/A

Molecular Weight

31.5 kDa

Storage Temp.

-20°C

Shipping

Gel Pack

Shelf Life

1 year

Concentration

N/A

Appearance

Lyophilized powder

Physical form description

Sterile filtered through a 0.2 micron filter. Lyophilized from 1 x PBS, pH 7.2.

Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Handling

Centrifuge the vial prior to opening.

Usage

For Research Use Only! Not to be used in humans

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Description

IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.

Additional source

Recombinants or rec. proteins

Group

recombinants