Rottlerin for cell activation

Catalog number
1827-10
Name
Rottlerin for cell activation
Size
10 mg
Price
153.00 EUR
Supplier

Details

Description
Originally reported as an inhibitor of Protein Kinase C isoforms with selectivity for PKCδ. However, more recent studies have shown Rottlerin did not block PKCδ activity but did block other kinase and non-kinase proteins in vitro and activated multiple Ca²⁺-sensitive K⁺ channels with high potency. It uncouples mitochondria and affects mitochondrial production of reactive oxygen species (ROS). Also induces autophagy through inhibition of mTORC1.
Peptide sequence
N/A
CAS number
82-08-6
Molecular weight
516.55
Category
Biochemicals
Other name
3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone; Mallotoxin
Molecular formula
C₃₀H₂₈O₈
Physical appearance
Orange to brown solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
No
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (30 mg/ml) or Ethanol (1 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.