Rottlerin for cell activation

Originally reported as an inhibitor of Protein Kinase C isoforms with selectivity for PKCδ. However, more recent studies have shown Rottlerin did not block PKCδ activity but did block other kinase and non-kinase proteins in vitro and activated multiple Ca²⁺-sensitive K⁺ channels with high potency. It uncouples mitochondria and affects mitochondrial production of reactive oxygen species (ROS). Also induces autophagy through inhibition of mTORC1.

N/A

82-08-6

516.55

Biochemicals

3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone; Mallotoxin

C₃₀H₂₈O₈

Orange to brown solid

N/A

No

No

≥98% by HPLC

DMSO (30 mg/ml) or Ethanol (1 mg/ml)

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.