Calpain Inhibitor II, ALLM for cell activation

A cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.

N-Acetyl-Leu-Leu-Methional

136632-32-1

401.57

Biochemicals

Ac-LLM-CHO, N-Acetyl-Leu-Leu-Methional

C₁₉H₃₅N₃O₄S

White powder

N/A

No

Yes

≥95% by HPLC

DMSO (25 mg/ml) or EtOH (25 mg/ml)

-20°C

gel pack

24 months

Protect from moisture and air

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.