Rocaglamide for cell activation

An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.

N/A

84573-16-0

505.56

Biochemicals

Rocaglamide A

C₂₉H₃₁NO₇

White to off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO or EtOH

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.