SC66 for cell activation

Cell-permeable. An allosteic Akt inhibitor that directly facilitates Akt ubiquitination in vitro and in vivo. SC66 displays a dual inhibitory activity that directly interferes with the pleckstrin homology (PH) domain binding to PIP₃ and facilitates Akt ubiquitination. Due to its dual inhibitory activity, SC66 displays a more effective growth suppression of transformed cells that contain a high level of Akt signaling, compared with other inhibitors of PIP₃/Akt pathway.

N/A

871361-88-5

276.33

Biochemicals

(2E, 6E)-2, 6-Bis(pyridine-4ylmethylene)cyclohexanone

C₁₈H₁₆N₂O

Yellow crystalline solid

N/A

No

Yes

≥95% by HPLC

DMSO

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.