GDC-0449 for cell activation

Catalog number
1890-25
Name
GDC-0449 for cell activation
Size
25 mg
Price
616.00 EUR
Supplier

Details

Description
A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
Peptide sequence
N/A
CAS number
879085-55-9
Molecular weight
421.3
Category
Biochemicals
Other name
2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Molecular formula
C₁₉H₁₄Cl₂N₂O₃S
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.