Nimbolide for cell activation

A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.

N/A

25990-37-8

466.52

Biochemicals

(4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909

C₂₇H₃₀O₇

White to off-white solid

N/A

No

Yes

≥98% by TLC

DMSO (~50 mM) or Ethanol (~ 8 mM)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.