NSC 146109 hydrochloride for cell activation

Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.

N/A

59474-01-0

316.85

Biochemicals

(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011

C₁₇H₁₆N₂S.HCl

Yellow solid

N/A

No

Yes

≥98% by HPLC

DMSO (100 mM) or EtOH (10 mM)

-20°C

gel pack

36 months

Protect from moisture

cell

For cells, cell lines and tissues in culture till half confluency.