JM6 for cell activation

Cell-permeable. A slow-release prodrug version of Ro 61-8048 (Cat. No. 1912-5, 25), an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to be implicated in neurodegeneration. JM6 reverses and prevents symptoms of neurodegenerative diseases like Alzheimer’s and Huntington’s in animal models. JM6 does not penetrate into the brain, but works by inhibiting KMO in the blood.

N/A

N/A

518.61

Biochemicals

2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-Nitrophenyl)-5-(Piperidin-1-yl)Methylthiazole

C₂₃H₂₆N₄O₆S₂

Off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO

-20°C

gel pack

36 months

Protect from light

cell

For cells, cell lines and tissues in culture till half confluency.