SU 11274 for cell activation

A specific, ATP-competitive small molecule inhibitor of the catalytic activity of Met. Displays selectivity for Met enzyme versus a panel of other tyrosine kinases with the following IC₅₀ values: Met = 0.02 μM, Flk = 1.3 μM, EGFR = >100 μM, PDGFßR = >20 μM, Tie2 = >100 μM, c-src = >10 μM, cdk2 = >10 μM, and FGFR-1 = 9.7 μM). Inhibition of the Met kinase activity by SU11274 leads to time- and dose-dependent reduced cell growth and induced G1 cell cycle arrest and apoptosis.

N/A

658084-23-2

568.09

Biochemicals

3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide

C₂₈H₃₀ClN₅O₄S

Orange solid

N/A

No

Yes

≥98% by HPLC

DMSO (~ 10 mg/ml on warming)

-20°C

gel pack

36 months

Protect from light

cell

For cells, cell lines and tissues in culture till half confluency.