Ro 31-8220 methanesulfonate for cell activation
Catalog number
1946-1
Name
Ro 31-8220 methanesulfonate for cell activation
Size
1 mg
Price
137.00 EUR
Supplier
Details
Description
Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC₅₀ = 0.9 μM) and calcium/calmodulin kinase II (IC₅₀ = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 6.8 nM).
Peptide sequence
N/A
CAS number
138489-18-6
Molecular weight
553.65
Category
Biochemicals
Other name
2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; BIM IX
Molecular formula
C₂₅H₂₃N₅O₂S.CH₄O₃S
Physical appearance
Red solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by NMR
Reconstitute instructions
DMSO (~ 100 mg/ml) or water (~ 5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
