GSK-3 Inhibitor, AR-A014418 for cell activation

Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

N/A

487021-52-3

308.31

Biochemicals

N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea

C₁₂H₁₂N₄O₄S

Off-white solid

N/A

No

Yes

≥98% by TLC

DMSO (30 mg/ml)

-20°C

gel pack

48 months

Protect from light and air

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.