Vinorelbine Tartrate for cell activation

A semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent. At high concentrations, it stimulates microtubule depolymerization and mitotic spindle destruction. At lower clinically relevant concentrations, vinorelbine blocks mitotic progression. Its main targets are tubulin and microtubules. Unlike the taxanes, which bind poorly to soluble tubulin, vinorelbine can bind both soluble and microtubule-associated tubulin.

N/A

125317-39-7

1079.11

Biochemicals

3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate

C₄₅H₅₄N₄O₈.C₈H₁₂O₁₂

Off-white solid

N/A

No

Yes

≥98% by HPLC

Water (~ 10 mg/ml)

-20°C

gel pack

48 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.