StemRegenin 1 for cell activation

A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.

N/A

N/A

466

Biochemicals

4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol hydrochloride; SR1

C₂₄H₂₃N₅OS.HCl

White solid

N/A

No

Yes

≥98% by HPLC

DMSO (~ 10 mM)

-20°C

gel pack

48 months

Protect from light and air

cell

For cells, cell lines and tissues in culture till half confluency.