Emetine dihydrochloride for cell activation

A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.

N/A

316-42-7

553.56

Biochemicals

2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline

C₂₉H₄₀N₂O₄·2HCl

White to off-white solid

N/A

No

No

≥98% by titration

Water (~ 100 mg/ml)

+4°C

gel pack

48 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.