Myeloperoxidase Inhibitor for cell activation

A potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC₅₀ = 300 nM). Does not affect catalase or glutathione peroxidase activities. Also displays no effect on the production of superoxide by neutrophils. Shown to inhibit H₂O₂-induced apoptosis in HL-60, human leukemia cells.

N/A

5351-17-7

151.17

Biochemicals

4-Aminobenzoic hydrazide; MPO Inhibitor; 4-ABH

C₇H9N₃O

White to off-white solid

N/A

No

Yes

≥95% by HPLC

DMSO

-20°C

gel pack

48 months

Protect from light and mositure

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.