Tubacin for cell activation

Catalog number
1984-250
Name
Tubacin for cell activation
Size
250 µg
Price
148.00 EUR
Supplier

Details

Description
Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC₅₀ = 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits α-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of α-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated α-tubulin deacetylation in mammalian cells.
Peptide sequence
N/A
CAS number
537049-40-4
Molecular weight
721.86
Category
Biochemicals
Other name
N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Molecular formula
C₄₁H₄₃N₃O₇S
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 10 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
60 months
Storage instructions
Protect from light and mositure
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.