LDN193189 for cell activation

Cell-permeable. LDN193189 is a small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively).It only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. LDN-193189 has been used to reduce ectopic ossification in a mouse model. The role of BMP2 signals in the growth and angiogenesis of non-small-cell lung carcinoma (NSCLC) also suggest LDN-193189 may be a potent inhibitor of lung tumors.

N/A

1062368-24-4 (free base)

442.94

Biochemicals

6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine, hydrochloride; DM-3189

C₂₅H₂₂N₆.HCl

Yellow solid

N/A

No

Yes

≥97% by HPLC

DMSO (10 mM)

-20°C

gel pack

24months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.