Quizartinib for cell activation

Cell-permeable. A second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular autophosphorylation assays (IC₅₀ = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3).  It inhibits the growth of human leukemia cell line MV4-11 (IC₅₀0 = 0.56 nM) which is FLT3 dependent and contains a homozygous FLT3-ITD mutation, and A375 cells (IC50 > 10,000 nM) which are not FLT3 dependent and contain an activating mutation in BRAF. 

N/A

950769-58-1

560.67

Biochemicals

AC220; AC010220

C₂₉H₃₂N₆O₄S

Off-white solid

N/A

No

Yes

≥99% by HPLC

DMSO (~200 mg/ml)

-20°C

gel pack

24months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.