RO4929097 for cell activation

Catalog number
2011-5
Name
RO4929097 for cell activation
Size
5 mg
Price
480.00 EUR
Supplier

Details

Description
RO4929097 is a small molecule γ-secretase inhibitor (IC₅₀ = 4 nM). It binds to γ-secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.
Peptide sequence
N/A
CAS number
847925-91-1
Molecular weight
469.4
Category
Biochemicals
Molecular formula
C₂₂H₂₀F₅N₃O₃
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.