RO4929097 for cell activation

RO4929097 is a small molecule γ-secretase inhibitor (IC₅₀ = 4 nM). It binds to γ-secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.

N/A

847925-91-1

469.4

Biochemicals

C₂₂H₂₀F₅N₃O₃

Off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO

-20°C

gel pack

24months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.