WP-1130 for cell activation

Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2 signaling via JAK2 ubiquitination.

N/A

856243-80-6

384.27

Biochemicals

(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide; Degrasyn

C₁₉H₁₈BrN₃O

Pale yellow solid

N/A

No

Yes

≥98% by TLC

DMSO (40 mg/ml) or EtOH (25 mg/ml)

-20°C

gel pack

24months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.