Neratinib for cell activation

Cell-permeable. A second-generation inhibitor of the ErbB family of receptor kinases. Neratinib acts as an irreversible inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases by targeting a cysteine residue in the ATP-binding site of the receptor. It inhibits the proliferation of HER-2 overexpressing human breast cancer cell lines and EGFR-dependent cells in vitro. 

N/A

698387-09-6

557.04

Biochemicals

HKI-272

C₃₀H₂₉ClN₆O₃

Off-white to pale yellow solid

N/A

No

Yes

≥98% by HPLC

DMSO (~ 2 mg/ml)

-20°C

gel pack

24 months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.