TAME Hydrochloride for cell activation
Catalog number
2050-500
Name
TAME Hydrochloride for cell activation
Size
500 mg
Price
338.00 EUR
Supplier
Details
Description
A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination.
Peptide sequence
N/A
CAS number
1784-03-8
Molecular weight
378.87
Category
Biochemicals
Other name
N-p-Tosyl-L-arginine methyl ester hydrochloride
Molecular formula
C₁₄H₂₂N₄O₄S.HCl
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
No
Purification
≥98% by TLC
Reconstitute instructions
Water (50 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
