YC-1 for cell activation

Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor. YC-1 also inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.

N/A

170632-47-0

304.34

Biochemicals

3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole

C₁₉H₁₆N₂O₂

White to pale yellow solid

N/A

N/A

Yes

≥98% by NMR

DMSO (100 mM) or EtOH (50 mM)

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.