TAPI-1 for cell activation
Catalog number
2068-1
Name
TAPI-1 for cell activation
Size
1 mg
Price
387.00 EUR
Supplier
Details
Description
Inhibitor of TNF-α processing (IC₅₀ = 100 nM), similar to TAPI-0 (Cat. No. 2067-1), but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α (IC₅₀ = 50-100 μM), APP (1-8 μM), IL6R (5- 10 μM), TNFRI (5 -10 μM), TNFRII (25 -50 μM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.
Peptide sequence
N/A
CAS number
171235-71-5
Molecular weight
499.3
Category
Biochemicals
Other name
N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide; TNF protease inhibitor-0; C1
Molecular formula
C₂₆H₃₇N₅O₅
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
No
Purification
≥95% by HPLC
Reconstitute instructions
DMSO and MEOH
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
