S-Adenosyl-L-methionine disulfate tosylate for cell activation
Catalog number
2077-500
Name
S-Adenosyl-L-methionine disulfate tosylate for cell activation
Size
500 mg
Price
567.00 EUR
Supplier
Details
Description
A methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
Peptide sequence
N/A
CAS number
97540-22-2
Molecular weight
766.8
Category
Biochemicals
Other name
AdoMet SAM disulfate p-toluenesulfonate; SAMe
Molecular formula
C₁₅H₂₂N₆O₅S.C₇H₁₂O₁₁S₂
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
No
Purification
≥95% by HPLC
Reconstitute instructions
H₂O (~100 mg/ml)
Storage condition
-20°C
Shipping condition
Dry ice
Maximum time for storage
24 months
Storage instructions
Protect from moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
