Flavopiridol for cell activation

Cell-permeable. Flavopiridol is a synthetic flavonoid compound used as an anticancer agent. It is a serine/threonine kinase inhibitor that broadly targets cyclin-dependent kinases (CDKs), including the cyclin 9/cyclin T complex (pTEF-b), preventing activation of RNA polymerase II. Flavopiridol initiates cell cycle arrest and p53-independent apoptosis through down-regulation of Mcl-1 and X-linked inactivator of apoptosis (XIAP).

N/A

146426-40-6

401.84

Biochemicals

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4-chromenone; HMR 1275; L86-8275; NSC 649890

C₂₁H₂₀ClNO₅

Yellow solid

N/A

N/A

Yes

≥98% by HPLC

DMSO (~15 mg/ml ) or Ethanol (~ 8 mg/ml)

-20°C

gel pack

24 months

Protect from light

cell

For cells, cell lines and tissues in culture till half confluency.