Flavopiridol for cell activation

Catalog number
2090-1
Name
Flavopiridol for cell activation
Size
1 mg
Price
148.00 EUR
Supplier

Details

Description
Cell-permeable. Flavopiridol is a synthetic flavonoid compound used as an anticancer agent. It is a serine/threonine kinase inhibitor that broadly targets cyclin-dependent kinases (CDKs), including the cyclin 9/cyclin T complex (pTEF-b), preventing activation of RNA polymerase II. Flavopiridol initiates cell cycle arrest and p53-independent apoptosis through down-regulation of Mcl-1 and X-linked inactivator of apoptosis (XIAP).
Peptide sequence
N/A
CAS number
146426-40-6
Molecular weight
401.84
Category
Biochemicals
Other name
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4-chromenone; HMR 1275; L86-8275; NSC 649890
Molecular formula
C₂₁H₂₀ClNO₅
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~15 mg/ml ) or Ethanol (~ 8 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.