Nigericin sodium salt for cell activation
Catalog number
2096-5
Name
Nigericin sodium salt for cell activation
Size
5 mg
Price
148.00 EUR
Supplier
Details
Description
Nigericin is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K⁺> Rb⁺ Cs⁺>> Na⁺. Also activates NLRP3/NALP3 and signals through pannexin-1 to induce caspase-1 maturation and IL-1β processing and release.
Peptide sequence
N/A
CAS number
28643-80-3
Molecular weight
746.94
Category
Biochemicals
Other name
Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A; BRN 169675
Molecular formula
C₄₀H₆₇NaO₁₁
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
No
Purification
≥98% by TLC
Reconstitute instructions
DMSO (~50 mg/ml) or Ethanol (~20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
