Human CellExp™ KIM3/HAVCR2, human recombinant

KIM3/HAVCR2

Hepatitis A virus cellular receptor 2 also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

N/A

This protein is fused with the Fc region of human IgG1 at the C-terminus and has a calculated MW of 42 kDa after removal of signal peptide. In DTT-reduced SDS-PAGE, rhKIM3-Fc protein migrates as 45 kDa poly peptide due to glycosylation.

HAVCR2, TIM3, TIMD3, FLJ14428, KIM3

HAVCR2, TIM3, TIMD3, FLJ14428, KIM3

84868

HAVCR2

Human

Q8TDQ0

Yes

HEK293 cells

≥97%

SDS-PAGE, N/A

N/A

Measured by its binding ability in a functional ELISA. Immobilized rh-Galectin-9 at 500 ng/ml can bind rhKIM3-Fc with an apparent KD

Measured by its binding ability in a functional ELISA. Immobilized rh-Galectin-9 at 500 ng/ml can bind rhKIM3-Fc with an apparent KD

N/A

N/A

-20°C

Gel Pack

Lyophilized

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

N/A

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Recombinants or rec. proteins

recombinants