TACE (TNF-α converting enzyme), human recombinant

Catalog number

7607-20

Size

20 μg

Price

445.00 EUR

Supplier

Biovision

Order

Details

Synonyms

Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b

Alternates names

Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme

Taglines

Involved in the processing of TNF-α at the surface of cells

Biomolecule/Target

NCBI Gene ID #.

6868

NCBI Gene Symbol

ADAM17

Gene Source

Human

Accession #

P78536

Recombinant

Yes

Source

Insect cell

Purity

N/A

Endotoxin Level

N/A

Activity (Specifications/test method)

≥ 280 units/mg

Biological activity

Activity of TACE was tested using the synthetic peptide, Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa(Dnp)-NH2, as a substrate.

Results

N/A

Molecular Weight

62 kDa

Storage Temp.

-70°C

Shipping

gel pack

Shelf Life

1 year

Concentration

N/A

Appearance

Lyophilized powder

Physical form description

The untagged rh-TACE (TNF-alpha converting enzyme) is supplied as a lyophilized powder.

Reconstitution Instructions

With sterile deionized water at 0.1µg protein/µl.

Handling

Centrifuge the vial prior to opening.

Usage

For Research Use Only! Not to be used in humans

Description

Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Additional source

Recombinants or rec. proteins

Group

recombinants

Gene

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.