Auranofin for cell activation
Catalog number
2219-10
Name
Auranofin for cell activation
Size
10 mg
Price
121.00 EUR
Supplier
Details
Description
An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition via the inhibition of mitochondrial thioredoxin reductase (TrxR).
Peptide sequence
N/A
CAS number
34031-32-8
Molecular weight
678.48
Category
Biochemicals
Other name
1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate; SKF39162
Molecular formula
C₂₀H₃₄AuO₉PS
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by NMR
Reconstitute instructions
DMSO (100 mM) or Ethanol (50 mM)
Storage condition
RT
Shipping condition
RT
Maximum time for storage
24 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
