Smad3 Inhibitor, SIS3 for cell activation

A potent and selective inhibitor of Smad3 function. SIS3 selectively inhibits TGF-β1/ALK5-induced Smad3 phosphorylation. Also inhibits the TGF-β1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site.

N/A

521984-48-5

489.99

Biochemicals

(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

C₂₈H₂₇N₃O₃ ∙ HCl

Yellow solid

N/A

No

Yes

≥98% by HPLC

DMSO (>20 mg/ml)

-20°C

gel pack

24 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.