TRIM24 bromodomain (896-1014 aa) (GST-tagged), Human recombinant

Catalog number
7658-100
Name
TRIM24 bromodomain (896-1014 aa) (GST-tagged), Human recombinant
Size
100 μg
Price
697.00 EUR
Supplier

Details

Target
TRIM24
Background
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TRIM24 is a transcriptional cofactor, whose inactivation leads to hepatocellular carcinoma in mice.3 The N-terminal TRIM domain of TRIM24 binds ligand-bound nuclear receptors, while its tandem C-terminal plant homeo-domain and bromodomain target TRIM24 to acetylated histones in chromatin. This product contains the bromodomain region of TRIM24.
Concentration
N/A
Molecular weight
40.9 kDa (896-1014 aa + NT GST Tag)
Synonym
TRIM24 bromodomain (896-1014 aa) (GST-tagged), Human recombinant
Other name
Transcriptional Intermediary Factor 1-α; E3 Ubiquitin-protein Ligase TRIM24; hTIF1; RING finger protein 82; RNF82; PTC6; Tripartite Motif Containing 24.
NCBI gene number
8805
NCBI gene
TRIM24
Gene source
Human
NCBI number
O15164
Recombinant
Yes
Source
E. coli
Purification
≥95%
Tested applications
SDS-PAGE, HPLC
Level of endotoxin
N/A
Tested activity
N/A
Biological activity
N/A
Reesults
N/A
Binding ability
N/A
Unit
N/A
Storage condition
-80°C
Shipping under
dry ice
Physical appearance
Liquid
Physical properties
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
How to reconstitute
N/A
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants