CECR2 bromodomain (424-538 aa) (GST-tagged), Human recombinant

CECR2

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. Cat eye syndrome critical region protein 2 (CECR2) is a transcription factor that forms a heterodimeric complex with the ATP-dependent chromatin remodeler SNF2L forming the CECR2-containing-remodeling factor (CERF). The CERF complex plays a critical role in neurulation. More recently, the bromodomain of CECR2 was shown to have strong γ-H2AX inhibition activity suggesting that CECR2 may play a role in DNA damage response.

N/A

40.6 kDa (424-538 aa + NT GST Tag)

CECR2 bromodomain (424-538 aa) (GST-tagged), Human recombinant

Cat Eye Syndrome Critical Region Protein 2

27443

CECR2

Human

Q9BXF3

Yes

E. coli

≥95%

SDS-PAGE, HPLC

N/A

N/A

N/A

N/A

N/A

N/A

-80°C

dry ice

Liquid

50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol.

N/A

N/A

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Recombinants or rec. proteins

recombinants