BRPF3 bromodomain (576-701 aa) (GST-tagged), Human recombinant

BRPF3

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. Bromodomain and PHD finger containing 3 (BRPF3) is a component of the MOZ/MORF histone acetyltransferase (HAT) complex. The addition of BRPF proteins to MOZ/MORF increases its HAT activity.3 Consequently, BRPF3 is likely to play a role in regulation of transcriptional activation by MOZ/MORF. This product contains the first bromodomain of BRPF3.

N/A

41.2 kDa (576-701 aa + NT GST Tag)

BRPF3 bromodomain (576-701 aa) (GST-tagged), Human recombinant

Bromodomain and PHD Finger Containing 3; KIAA1286; MGC:58603

27154

BRPF3

Human

Q9ULD4

Yes

E. coli

≥95%

SDS-PAGE, HPLC

N/A

N/A

N/A

N/A

N/A

N/A

-80°C

dry ice

Liquid

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

N/A

N/A

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Recombinants or rec. proteins

recombinants