GSK-J4 hydrochloride for cell activation
Catalog number
2259-1
Name
GSK-J4 hydrochloride for cell activation
Size
1 mg
Price
115.00 EUR
Supplier
Details
Description
Cell-permeable. An ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (Cat. No. 2260-1, 5) (IC₅₀> 50 μM in vitro. When administered to human primary macrophages, GSK-J4 can reduce lipopolysaccharide (LPS)-induced proinflammatory cytokine production, most notably including that of TNFα (IC₅₀ = 9 µM).
Peptide sequence
No
CAS number
N/A
Molecular weight
454.00
Category
Biochemicals
Other name
Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2--(pyridin-2- yl)pyrimidin-4-yl)amino)propanoate, monohydrochloride
Molecular formula
C₂₄H₂₇N₅O₂ ∙ HCl
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95%
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from light and mositure
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
